Nature provides numerous ecological, physical, cultural and spiritual benefits to city-dwellers. Cities in turn can play a critical role in protecting natural ecosystems. Through careful land use planning, habitat restoration and animal-friendly infrastructure, cities can prosper while harboring local biodiversity and reducing negative impacts on regional and global biodiversity. Data-driven target-setting, operationalization and monitoring can help ensure that biodiversity initiatives are effective. Additionally, inclusive governance, respect for traditional practices and equity-centered implementation serve to prevent the "nature vs. people" conflicts that tend to derail urban biodiversity programs, ensuring that such initiatives benefit both people and the planet.